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Meta-Analysis of Transcriptome-Wide Association Studies across 13 Brain Tissues Identified Novel Clusters of Genes Associated with Nicotine Addiction.

Genes - 23 Dec 2021

Ye Zhenyao, Mo Chen, Ke Hongjie, Yan Qi, Chen Chixiang, Kochunov Peter, Hong L Elliot, Mitchell Braxton D, Chen Shuo, Ma Tianzhou

Abstract excerpt

Genome-wide association studies (GWAS) have identified and reproduced thousands of diseases associated loci, but many of them are not directly interpretable due to the strong linkage disequilibrium among variants. Transcriptome-wide association studies (TWAS) incorporated expression quantitative trait loci (eQTL) cohorts as a reference panel to detect associations with the phenotype at the gene level and have...

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Identifiers

PMID: 35052378
DOI: 10.3390/genes13010037
PMCID: PMC8775257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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