Article
Evidence of CNIH3 involvement in opioid dependence.
Molecular psychiatry - 1 May 2016
Nelson E C, Agrawal A, Heath A C, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas M R, Chou Y-L, Demers C H, Carey C E, Conley E D, Fakira A K, Farrer L A, Goate A, Gordon S, Henders A K, Hesselbrock V, Kapoor M, Lynskey M T, Madden P A F, Moron J A, Rice J P, Saccone N L, Schwab S G, Shand F L, Todorov A A, Wallace L, Wang T, Wray N R, Zhou X, Degenhardt L, Martin N G, Hariri A R, Kranzler H R, Gelernter J, Bierut L J, Clark D J, Montgomery G W
Abstract excerpt
Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data comparing opioid-dependent daily injectors (N=1167) with opioid misusers who never progressed to daily injection (N=161). The strongest associations, observed for CNIH3 single-nucleotide polymorphisms (SNPs),...
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