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Article

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.

The Journal of clinical investigation - 1 Sept 2013

Andronesi Ovidiu C, Rapalino Otto, Gerstner Elizabeth, Chi Andrew, Batchelor Tracy T, Cahill Dan P, Sorensen A Gregory, Rosen Bruce R

Abstract excerpt

The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence,...

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Source

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Identifiers

PMID: 23999439
DOI: 10.1172/JCI67229
PMCID: PMC3754248

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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