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Article

Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2016

Andronesi Ovidiu C, Loebel Franziska, Bogner Wolfgang, Marjańska Małgorzata, Vander Heiden Matthew G, Iafrate A John, Dietrich Jorg, Batchelor Tracy T, Gerstner Elizabeth R, Kaelin William G, Chi Andrew S, Rosen Bruce R, Cahill Daniel P

Abstract excerpt

PURPOSE: Measurements of objective response rates are critical to evaluate new glioma therapies. The hallmark metabolic alteration in gliomas with mutant isocitrate dehydrogenase (IDH) is the overproduction of oncometabolite 2-hydroxyglutarate (2HG), which plays a key role in malignant transformation. 2HG represents an ideal biomarker to probe treatment response in IDH-mutant glioma patients, and we hypothesized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26534967
DOI: 10.1158/1078-0432.CCR-15-0656
PMCID: PMC4818725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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