Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss.

Journal of the Association for Research in Otolaryngology : JARO - 1 Dec 2013

Oishi Naoki, Chen Jun, Zheng Hong-Wei, Hill Kayla, Schacht Jochen, Sha Su-Hua

Abstract excerpt

Exogenous tumor necrosis factor-alpha (TNF-α) plays a role in auditory hair cell death by altering the expression of apoptosis-related genes in response to noxious stimuli. Little is known, however, about the function of TNF-α in normal hair cell physiology. We, therefore, investigated the cochlear morphology and auditory function of TNF-α-deficient mice. Auditory evoked brainstem response showed significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cochlea
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TNF gene

Share to Hair Cells, Auditory, Outer

Share to Hearing Loss

Share to Mutation

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 23996384
DOI: 10.1007/s10162-013-0410-3
PMCID: PMC3825018

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss.PMID 23996384Read ↗

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice.Semantic proximity Read ↗

Endogenous SIRT3 activity is dispensable for normal hearing recovery after noise exposure in young adult miceSemantic proximity Read ↗

Age-related degeneration of the organ of Corti in two genotypes of mice.Semantic proximity Read ↗

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing LossSemantic proximity Read ↗

Inner ear morphology in CBA/Ca and C57BL/6J mice in relationship to noise, age and phenotype.Semantic proximity Read ↗

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss.Semantic proximity Read ↗

Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase.Semantic proximity Read ↗

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss.Semantic proximity Read ↗

Anatomical, metabolic and genetic aspects of age-related hearing loss in mice.Semantic proximity Read ↗

The p75 neurotrophin receptor protects primary auditory neurons against acoustic trauma in mice.Semantic proximity Read ↗

CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem.Semantic proximity Read ↗

Inner ear dysfunction in caspase-3 deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.