Article
Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss.
Hearing research - 1 Mar 2017
Vlajkovic Srdjan M, Ambepitiya Kaushi, Barclay Meagan, Boison Detlev, Housley Gary D, Thorne Peter R
Abstract excerpt
Our previous studies have shown that the stimulation of A1 adenosine receptors in the inner ear can mitigate the loss of sensory hair cells and hearing loss caused by exposure to traumatic noise. Here, we focus on the role of adenosine receptors (AR) in the development of noise-induced neural injury in the cochlea using A1AR and A2AAR null mice (A1AR-/- and A2AAR-/-). Wildtype (WT) and AR deficient mice were...
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