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Article

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004

Rüttiger Lukas, Sausbier Matthias, Zimmermann Ulrike, Winter Harald, Braig Claudia, Engel Jutta, Knirsch Martina, Arntz Claudia, Langer Patricia, Hirt Bernhard, Müller Marcus, Köpschall Iris, Pfister Markus, Münkner Stefan, Rohbock Karin, Pfaff Imke, Rüsch Alfons, Ruth Peter, Knipper Marlies

Abstract excerpt

The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells. BK channels have been shown to be composed of the pore-forming alpha-subunit coexpressed with the auxiliary beta1-subunit. Analyzing the hearing function and cochlear phenotype of BK channel alpha-(BKalpha-/-) and beta1-subunit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15328414
DOI: 10.1073/pnas.0402660101
PMCID: PMC516466

Genes

KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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