Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integration of mTOR and estrogen–ERK2 signaling in lymphangioleiomyomatosis pathogenesis

27 Aug 2013

Abstract excerpt

Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women associated with the metastasis of tuberin-null cells with hyperactive mammalian target of rapamycin complex 1 (mTORC1) activity. Clinical trials with the mTORC1 inhibitor rapamycin have revealed partial efficacy but are not curative. Pregnancy appears to exacerbate LAM, suggesting that estrogen (E2) may play a role in the unique features of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Tuberous Sclerosis Complex Research
Share to Vascular Tumors and Angiosarcomas

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23983265
DOI: 10.1073/pnas.1309110110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integration of mTOR and estrogen–ERK2 signaling in lymphangioleiomyomatosis pathogenesisPMID 23983265Read ↗

Lymphangioleiomyomatosis: where endocrinology, immunology and tumor biology meetSemantic proximity Read ↗

Lymphangioleiomyomatosis: Current understanding and potential treatments.Semantic proximity Read ↗

Hyperactive mTOR in Lung Mesenchyme Induces Endothelial Dysfunction and Pulmonary Vascular RemodelingSemantic proximity Read ↗

Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodelingSemantic proximity Read ↗

Lost in translation: a neglected mTOR target for lymphangioleiomyomatosisSemantic proximity Read ↗

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive CellsSemantic proximity Read ↗

Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management.Semantic proximity Read ↗

STAT1 Promotes PD-L1 Activation and Tumor Growth in LymphangioleiomyomatosisSemantic proximity Read ↗

Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies.Semantic proximity Read ↗

mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function declineSemantic proximity Read ↗

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.Semantic proximity Read ↗

Molecular Pathology of Lymphangioleiomyomatosis and Other Perivascular Epithelioid Cell TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.