Article

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells

2022-09-28

Abstract excerpt

<h4>ABSTRACT</h4> Lymphangioleiomyomatosis (LAM) is a rare, debilitating lung disease that predominantly affects women of reproductive age. LAM is characterized by the infiltration of the lungs by abnormally proliferating smooth muscle-like cells of unknown origin via an estrogen-dependent metastatic mechanism. LAM cells carry deleterious mutations of tuberous sclerosis complex (TSC1/TSC2) genes, resulting in hyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fca3fb5-46c2-5365-82e0-47dc6927cdef
DOI: 10.1101/2022.09.27.509560

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive CellsDOI 10.1101/2022.09.27.509560Read

Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cellsSemantic proximity Read

Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial TranscriptomicsSemantic proximity Read

Identification of the lymphangioleiomyomatosis cell and its uterine originSemantic proximity Read

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis CellSemantic proximity Read

mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function declineSemantic proximity Read

STAT1 Promotes PD-L1 Activation and Tumor Growth in LymphangioleiomyomatosisSemantic proximity Read

scRNA-seq and spatial transcriptomics reveal neuroendocrine-like cancer cells promote angiogenesis and EMT through neural signaling pathways in male breast cancerSemantic proximity Read

Multidimensional Single-Cell Transcriptomic Profiling of Uterine Leiomyosarcomas Reveals Distinct Tumor States with Inferred Therapeutic VulnerabilitiesSemantic proximity Read

Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomachSemantic proximity Read

Connectivity analysis of single cell RNA-sequencing derived transcriptional signature of lymphangioleiomyomatosisSemantic proximity Read

Lymphangioleiomyomatosis (LAM) Cell AtlasSemantic proximity Read

Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodelingSemantic proximity Read