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Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis

27 Sept 2023

Abstract excerpt

Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 activation enhances a plethora of anabolic cellular functions, mainlyviathe activation of mRNA translation through stimulation of ribosomal protein S6 kinase (S6K1)/ribosomal protein S6 (S6) and...

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PMID: 37758276
DOI: 10.1183/16000617.0100-2023

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