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Article

A biochemical analysis linking APOBEC3A to disparate HIV-1 restriction and skin cancer.

The Journal of biological chemistry - 11 Oct 2013

Pham Phuong, Landolph Alice, Mendez Carlos, Li Nancy, Goodman Myron F

Abstract excerpt

Human deoxycytidine deaminase APOBEC3A (Apo3A) acts as an HIV-1 restriction factor in cells of myeloid lineage yet functions separately as a potent mutator for genomic DNA. Apo3A activity and C motif deamination specificity exhibit a striking dependence on pH that reflects these two distinct biol...

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Identifiers

PMID: 23979356
DOI: 10.1074/jbc.M113.504175
PMCID: PMC3795231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23979356-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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