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APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

17 Sept 2018

Abstract excerpt

APOBEC enzymes are DNA cytosine deaminases that normally serve as virus restriction factors, but several members, including APOBEC3H, also contribute to cancer mutagenesis. Despite their importance in multiple fields, little is known about cellular processes that regulate these DNA mutating enzymes. We show that APOBEC3H exists in two distinct subcellular compartments, cytoplasm and nucleolus, and that the...

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PMID: 30224517
DOI: 10.1128/mcb.00356-18

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