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Article

Intestinal-specific TNFα overexpression induces Crohn's-like ileitis in mice.

PloS one - 1 Jan 2013

Bamias Giorgos, Dahman Mohamed I, Arseneau Kristen O, Guanzon Mitchell, Gruska Dennis, Pizarro Theresa T, Cominelli Fabio

Abstract excerpt

BACKGROUND AND AIM: Human and animal studies have clearly established tumor necrosis factor (TNF)α as an important mediator of Crohn's disease pathogenesis. However, whether systemic or only local TNFα overproduction is required for the development of chronic intestinal inflammation and Crohn's disease remains unclear. The aim of this study was to assess the contribution of intestinal epithelial-derived TNFα to...

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Identifiers

PMID: 23977323
DOI: 10.1371/journal.pone.0072594
PMCID: PMC3748077

Genes

TNF

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