Article
A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice.
Inflammatory bowel diseases - 10 Apr 2025
Chilukuri Amruth, Kim Margaret, Mitra Taniya, Gubatan John M, Urrete Josef, Saxon Leo D, Ablack Amber, Mikulski Zbigniew, Dobaczewska Katarzyna, Shen Zining, Keir Mary, Yi Tangsheng, Kaur Prabhdeep, Oliveira Patricia, Murillo-Saich Jessica, Chang Eric Y, Steiner Calen A, Jedlicka Paul, Guma Mónica, Rivera-Nieves Jesús
Abstract excerpt
BACKGROUND: Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays a critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability of its mRNA transcript, determined in part by destabilizing sequences in its AAUU repeats (ARE) gene region, is an important regulator of its tissue and systemic levels. A deletion in the ARE region of the gene...
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