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Harnessing murine models of Crohn's disease ileitis to advance concepts of pathophysiology and treatment.

Mucosal immunology - 1 Jan 2022

Iliopoulou Lida, Kollias George

Abstract excerpt

Crohn's disease (CD) and ulcerative colitis (UC) are both characterized by chronic inflammation and severe dysfunction of the gastrointestinal tract. These two forms of inflammatory bowel disease (IBD) represent distinct clinical disorders with diverse driving mechanisms; however, this divergence is not reflected in currently approved therapeutics that commonly target general proinflammatory pathways. A...

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PMID: 34316007
DOI: 10.1038/s41385-021-00433-3

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