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Article

Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma.

Oncogene - 10 Jul 2014

Tallet A, Nault J-C, Renier A, Hysi I, Galateau-Sallé F, Cazes A, Copin M-C, Hofman P, Andujar P, Le Pimpec-Barthes F, Zucman-Rossi J, Jaurand M-C, Jean D

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a very aggressive tumor with no known curative treatment. Better knowledge of the molecular mechanisms of mesothelial carcinogenesis is required to develop new therapeutic strategies. MPM, like all cancer cells, needs to maintain telomere length to prevent...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to Lung Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesothelioma, Malignant

Share to Pleural Neoplasms

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Telomerase

Source

Identifiers

PMID: 23975423
DOI: 10.1038/onc.2013.351

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23975423-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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