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Article

TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma.

Oncotarget - 30 Oct 2014

Xie Hong, Liu Tiantian, Wang Na, Björnhagen Viveca, Höög Anders, Larsson Catharina, Lui Weng-Onn, Xu Dawei

Abstract excerpt

Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis. The regulatory mechanism and clinical significance underlying cancer-specific TERT expression have been extensively investigated in various human malignancies, but little is known about these in Merkel cell carcinoma (MCC), an aggressive neuroendocrine skin tumor. Here we addressed these issues by...

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Share to Carcinoma, Merkel Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 25301727
DOI: 10.18632/oncotarget.2491
PMCID: PMC4259404

Genes

TERT
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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