Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival.

doi:10.1002/1878-0261.12651

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Article

Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival.

Molecular oncology - 1 Jun 2020

Quetel Lisa, Meiller Clément, Assié Jean-Baptiste, Blum Yuna, Imbeaud Sandrine, Montagne François, Tranchant Robin, de Wolf Julien, Caruso Stefano, Copin Marie-Christine, Hofman Véronique, Gibault Laure, Badoual Cécile, Pintilie Ecaterina, Hofman Paul, Monnet Isabelle, Scherpereel Arnaud, Le Pimpec-Barthes Françoise, Zucman-Rossi Jessica, Jaurand Marie-Claude, Jean Didier

Abstract excerpt

Development of precision medicine for malignant pleural mesothelioma (MPM) requires a deep knowledge of tumor heterogeneity. Histologic and molecular classifications and histo-molecular gradients have been proposed to describe heterogeneity, but a deeper understanding of gene mutations in the context of MPM heterogeneity is required and the associations between mutations and clinical data need to be refined. We...

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PMID: 32083805
DOI: 10.1002/1878-0261.12651
PMCID: PMC7266286

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