Article
Mutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2020
Campanella Nathália C, Silva Eduardo Caetano, Dix Gustavo, de Lima Vazquez Fabiana, Escremim de Paula Flávia, Berardinelli Gustavo N, Balancin Marcelo, Chammas Roger, Mendoza Lopez Rossana V, Silveira Henrique César S, Capelozzi Vera Luiza, Reis Rui Manuel
Abstract excerpt
BACKGROUND: Malignant pleural mesothelioma (MPM) is a highly lethal disease comprising a heterogeneous group of tumors with challenging to predict biological behavior. The diagnosis is complex, and the histologic classification includes 2 major subtypes of MPM: epithelioid (∼60% of cases) and sarcomatous (∼20%). Its identification depends upon pathological investigation supported by clinical and radiological...
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