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Article

Active site mutant Glu-43----Asp in staphylococcal nuclease displays nonlocal structural changes.

Biochemistry - 24 Jul 1990

Loll P J, Lattman E E

Abstract excerpt

The crystal structure of the Glu-43----Asp mutant of staphylococcal nuclease complexed with Ca2+ and the inhibitor thymidine 3',5'-bisphosphate (pdTp) has been determined and refined by restrained least-squares methods to a conventional crystallographic R value of 0.174 at a resolution of 1.74 A. Throughout most of the structure, the conformation of the backbone atoms of the mutant is similar to that of the...

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PMID: 2397218
DOI: 10.1021/bi00481a016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Active site mutant Glu-43----Asp in staphylococcal nuclease displays nonlocal structural changes.PMID 2397218Read ↗

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