Article
Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2013
Shen Hua, Eguchi Kosei, Kono Nozomu, Fujiu Katsuhito, Matsumoto Sahohime, Shibata Munehiko, Oishi-Tanaka Yumiko, Komuro Issei, Arai Hiroyuki, Nagai Ryozo, Manabe Ichiro
Abstract excerpt
OBJECTIVE: Obesity is a major risk factor of atherosclerotic cardiovascular disease. Circulating free fatty acid levels are known to be elevated in obese individuals and, along with dietary saturated fatty acids, are known to associate with cardiovascular events. However, little is known about the molecular mechanisms by which free fatty acids are linked to cardiovascular disease. APPROACH AND RESULTS: We found...
Topics
- Animals
- Carotid Artery Injuries
- Disease Models, Animal
- Fatty Acids
- Ligation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Myeloid Differentiation Factor 88
- Myocytes, Smooth Muscle
- NADH, NADPH Oxidoreductases