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Article

Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models.

PloS one - 1 Jan 2009

Tamura Takuya, Sone Masaki, Yamashita Mayumi, Wanker Erich E, Okazawa Hitoshi

Abstract excerpt

BACKGROUND: In several neurodegenerative disorders, toxic effects of glial cells on neurons are implicated. However the generality of the non-cell autonomous pathologies derived from glial cells has not been established, and the specificity among different neurodegenerative disorders remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: We newly generated Drosophila models expressing human mutant huntingtin (hHtt103Q)...

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Identifiers

PMID: 19165334
DOI: 10.1371/journal.pone.0004262
PMCID: PMC2622762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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