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Article

Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway.

Disease models & mechanisms - 1 Sept 2015

Szlachcic Wojciech J, Switonski Pawel M, Krzyzosiak Wlodzimierz J, Figlerowicz Marek, Figiel Maciej

Abstract excerpt

Huntington disease (HD) is a brain disorder characterized by the late onset of motor and cognitive symptoms, even though the neurons in the brain begin to suffer dysfunction and degeneration long before symptoms appear. There is currently no cure. Several molecular and developmental effects of HD have been identified using neural stem cells (NSCs) and differentiated cells, such as neurons and astrocytes. Still,...

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Identifiers

PMID: 26092128
DOI: 10.1242/dmm.019406
PMCID: PMC4582098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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