Article
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2009
Krentz Anthony D, Murphy Mark W, Kim Shinseog, Cook Matthew S, Capel Blanche, Zhu Rui, Matin Angabin, Sarver Aaron L, Parker Keith L, Griswold Michael D, Looijenga Leendert H J, Bardwell Vivian J, Zarkower David
Abstract excerpt
Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. Here, we show that in mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas, whereas these tumors do not form in Dmrt1 mutant C57BL/6J mice. Conditional gene targeting indicates that Dmrt1 is required in fetal germ...
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