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Article

The evolutionary landscape of the Mycobacterium tuberculosis genome.

Gene - 10 Apr 2013

Wang Tai-Chun, Chen Feng-Chi

Abstract excerpt

Mycobacterium tuberculosis is one of the most deadly human pathogens. The major mechanism for the adaptations of M. tuberculosis is nucleotide substitution. Previous studies have relied on the nonsynonymous-to-synonymous substitution rate (dN/dS) ratio as a measurement of selective constraint based on the assumed selective neutrality of synonymous substitutions. However, this assumption has been shown to be...

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Identifiers

PMID: 23219994
DOI: 10.1016/j.gene.2012.11.033

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