Article
The Nature and Evolution of Genomic Diversity in the Mycobacterium tuberculosis Complex.
Advances in experimental medicine and biology - 1 Jan 2017
Brites Daniela, Gagneux Sebastien
Abstract excerpt
The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of several mycobacterial lineages pathogenic to a range of different mammalian hosts. In this chapter, we discuss the origins and the evolutionary forces shaping the genomic diversity of the human-adapted MTBC. Advances in whole-genome sequencing have brought invaluable insights into the macro-evolution of the MTBC, and the biogeographical...
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