Article
High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography.
PLoS biology - 16 Dec 2008
Hershberg Ruth, Lipatov Mikhail, Small Peter M, Sheffer Hadar, Niemann Stefan, Homolka Susanne, Roach Jared C, Kremer Kristin, Petrov Dmitri A, Feldman Marcus W, Gagneux Sebastien
Abstract excerpt
Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds. For more than a century, scientists and clinicians have been distinguishing between the human- and animal-adapted members of the M. tuberculosis complex (MTBC). However, all human-adapted strains of MTBC have traditionally been considered to be essentially identical. We surveyed sequence diversity within...
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