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Article

Maternally transmitted mitochondrial DNA mutations can reduce lifespan.

Scientific reports - 9 Oct 2014

Ross Jaime M, Coppotelli Giuseppe, Hoffer Barry J, Olson Lars

Abstract excerpt

We recently showed that germline transmission of mitochondrial DNA mutations via the oocyte cause aggravation of aging phenotypes in prematurely aging mtDNA mutator (PolgA(mut/mut)) mice. We discovered that 32% of these mice also exhibit stochastic disturbances of brain development, when maternal mtDNA mutations were combined with homozygosity for the PolgA mutation, leading to de novo somatic mtDNA mutations....

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Identifiers

PMID: 25299268
DOI: 10.1038/srep06569
PMCID: PMC4190956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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