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Hereditary mtDNA heteroplasmy: a baseline for aging?

Cell metabolism - 1 Oct 2013

Keogh Michael, Chinnery Patrick F

Abstract excerpt

Do mtDNA mutations contribute to the aging process, or are they innocent bystanders? Ross et al. (2013) show that inherited mtDNA point mutations lead to a premature aging phenotype in mice and "prime" the maternal lineage, interacting with subsequent somatic mutations to cause brain malformations and shorten lifespan.

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PMID: 24093673
DOI: 10.1016/j.cmet.2013.09.015

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