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Article

Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2013

McWhinney-Glass Sarah, Winham Stacey J, Hertz Daniel L, Yen Revollo Jane, Paul Jim, He Yijing, Brown Robert, Motsinger-Reif Alison A, McLeod Howard L

Abstract excerpt

PURPOSE: The combination of a platinum and taxane are standard of care for many cancers, but the utility is often limited due to debilitating neurotoxicity. We examined whether single-nucleotide polymorphisms (SNP) from annotated candidate genes will identify genetic risk for chemotherapy-induced neurotoxicity. PATIENTS AND METHODS: A candidate-gene association study was conducted to validate the relevance of...

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Identifiers

PMID: 23963862
DOI: 10.1158/1078-0432.CCR-13-0774
PMCID: PMC3798385

Genes

BCL2
OPRM1
SOX10
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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