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Article

Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.

Journal of the neurological sciences - 15 Feb 2015

Johnson Cassandra, Pankratz Vernon S, Velazquez Ana I, Aakre Jeremiah A, Loprinzi Charles L, Staff Nathan P, Windebank Anthony J, Yang Ping

Abstract excerpt

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity secondary to chemotherapy. Genetic factors may be important in predisposing patients to this adverse effect. PATIENTS AND METHODS: We studied 950 primary lung cancer patients, who received platinum or platinum-combination drug chemotherapy and who had DNA available for study. We analyzed epidemiological risk factors in 279 CIPN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25586538
DOI: 10.1016/j.jns.2014.12.041
PMCID: PMC4334320

Genes

ABCC4
GPX7
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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