Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel.

doi:10.1158/1078-0432.CCR-13-3232

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Article

Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2014

Abraham Jean E, Guo Qi, Dorling Leila, Tyrer Jonathan, Ingle Susan, Hardy Richard, Vallier Anne-Laure, Hiller Louise, Burns Russell, Jones Linda, Bowden Sarah J, Dunn Janet A, Poole Christopher J, Caldas Carlos, Pharoah Paul P D, Earl Helena M

Abstract excerpt

PURPOSE: Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been replicated in large, independent validation studies. This study evaluates the association between previously investigated SNPs and TRSN, using genotype data from a study of chemotherapy-related toxicity in patients with breast cancer. EXPERIMENTAL...

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PMID: 24599932
DOI: 10.1158/1078-0432.CCR-13-3232

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ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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