Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia

21 Aug 2013

Abstract excerpt

Differentiation therapy has emerged as a powerful way to target specific hematologic malignancies. One of the best examples is the use of all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL), which has significantly improved the outcome for patients with this specific form of acute myeloid leukemia (AML). In considering how differentiation therapy could be used in other forms of AML, we predicted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23963861
DOI: 10.1158/1078-0432.ccr-12-2604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for LeukemiaPMID 23963861Read ↗

Differentiation therapy of acute myeloid leukemia: past, present and futureSemantic proximity Read ↗

Normal and malignant megakaryopoiesisSemantic proximity Read ↗

Amitotic Cell Division, Malignancy, and Resistance to Anticancer Agents: A Tribute to Drs. Walen and RajaramanSemantic proximity Read ↗

Differentiation therapy for myeloid malignancies: beyond cytotoxicity.Semantic proximity Read ↗

Differentiation therapy of myeloid leukemia: four decades of developmentSemantic proximity Read ↗

Nucleic acid therapeutics as differentiation agents for myeloid leukemiasSemantic proximity Read ↗

Human cell polyploidization: The good and the evilSemantic proximity Read ↗

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of CancerSemantic proximity Read ↗

Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1S34F mutant myelodysplastic neoplasms.Semantic proximity Read ↗

Differentiation therapy for solid tumorsSemantic proximity Read ↗

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic CellsSemantic proximity Read ↗

Revisiting the differentiation paradigm in acute promyelocytic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.