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Nucleic acid therapeutics as differentiation agents for myeloid leukemias

29 Feb 2024

Abstract excerpt

Differentiation therapy has proven to be a success story for patients with acute promyelocytic leukemia. However, the remaining subtypes of acute myeloid leukemia (AML) are treated with cytotoxic chemotherapies that have limited efficacy and a high likelihood of resistance. As differentiation arrest is a hallmark of AML, there is increased interest in developing differentiation-inducing agents to enhance...

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PMID: 38424137
DOI: 10.1038/s41375-024-02191-0

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