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Article

Collagenase-resistant collagen promotes mouse aging and vascular cell senescence.

Aging cell - 1 Feb 2014

Vafaie Faran, Yin Hao, O'Neil Caroline, Nong Zengxuan, Watson Alanna, Arpino John-Michael, Chu Michael W A, Wayne Holdsworth David, Gros Robert, Pickering J Geoffrey

Abstract excerpt

Collagen fibrils become resistant to cleavage over time. We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it. To test this, we followed mice with a targeted mutation (Col1a1(r/r) ) that yields collagenase-resistant type I collagen. Compared with wild-type littermates, Col1a1(r/r) mice had a shortened lifespan and developed features of premature aging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23957394
DOI: 10.1111/acel.12155
PMCID: PMC4326859

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