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Article

Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.

Circulation research - 12 Nov 2010

Rasi Karolina, Piuhola Jarkko, Czabanka Marcus, Sormunen Raija, Ilves Mika, Leskinen Hanna, Rysä Jaana, Kerkelä Risto, Janmey Paul, Heljasvaara Ritva, Peuhkurinen Keijo, Vuolteenaho Olli, Ruskoaho Heikki, Vajkoczy Peter, Pihlajaniemi Taina, Eklund Lauri

Abstract excerpt

RATIONALE: The extracellular matrix (ECM) is a major determinant of the structural integrity and functional properties of the myocardium in common pathological conditions, and changes in vasculature contribute to cardiac dysfunction. Collagen (Col) XV is preferentially expressed in the ECM of cardiac muscle and microvessels. OBJECTIVE: We aimed to characterize the ECM, cardiovascular function and responses to...

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PMID: 20847313
DOI: 10.1161/CIRCRESAHA.110.222133

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