Article
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2014
Eren Mesut, Boe Amanda E, Murphy Sheila B, Place Aaron T, Nagpal Varun, Morales-Nebreda Luisa, Urich Daniela, Quaggin Susan E, Budinger G R Scott, Mutlu Gökhan M, Miyata Toshio, Vaughan Douglas E
Abstract excerpt
Cellular senescence restricts the proliferative capacity of cells and is accompanied by the production of several proteins, collectively termed the "senescence-messaging secretome" (SMS). As senescent cells accumulate in tissue, local effects of the SMS have been hypothesized to disrupt tissue regenerative capacity. Klotho functions as an aging-suppressor gene, and Klotho-deficient (kl/kl) mice exhibit an...
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