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ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development

6 Oct 2006

Abstract excerpt

Genetic mutations in minor fibrillar collagen types Va1 (ColVa1) and XIa1 (ColXI) have been identified in connective tissue disorders including Ehlers-Danlos syndrome and chondrodysplasias. ColVa1+/- and ColXIa1-/- mutant mice recapitulate these human disorders and show aberrations in collagen fiber organization in connective tissue of the skin, cornea, cartilage, and tendon. In the heart, fibrous networks of...

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PMID: 17029294
DOI: 10.1002/dvdy.20980

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