Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A type XI collagen mutation leads to increased degradation of type II collagen in articular cartilage.

Osteoarthritis and cartilage - 1 Apr 2004

Rodriguez R R, Seegmiller R E, Stark M R, Bridgewater L C

Abstract excerpt

OBJECTIVE: To determine in articular cartilage whether degraded type II collagen is more abundant in Col11a1 mutant cho/+ than in age-matched +/+ mice and whether collagen degradation occurs in a generalized or localized fashion. DESIGN: Knee joints from cho/+ and +/+ mice at 6, 9, 12 and 15 months of age were dissected, fixed, cryosectioned, and stained with antibody COL2-3/4m against denatured type II collagen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage, Articular
Share to Collagen Type II
Share to Collagen Type XI

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hindlimb

Share to Immunohistochemistry

Share to Microscopy, Fluorescence

Share to Osteoarthritis

Share to Protein Denaturation

Source

Identifiers

PMID: 15023383
DOI: 10.1016/j.joca.2003.12.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A type XI collagen mutation leads to increased degradation of type II collagen in articular cartilage.PMID 15023383Read ↗

Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho).Semantic proximity Read ↗

Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice.Semantic proximity Read ↗

The role of collagen II and cartilage fibril-associated molecules in skeletal development.Semantic proximity Read ↗

Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a <i>COL2A1</i> -Related OsteoarthritisSemantic proximity Read ↗

Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a <i>COL2A1</i> -Related OsteoarthritisSemantic proximity Read ↗

Moderate forced running exercise induces cartilage adaptation but exacerbates the molecular cartilage phenotype of type IX collagen knockout mice.Semantic proximity Read ↗

Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta.Semantic proximity Read ↗

Ablation of the FACIT collagen XII disturbs musculoskeletal ECM organization and causes patella dislocation and myopathySemantic proximity Read ↗

Tendon and Motor Phenotypes in the <i> Crtap <sup>-/-</sup> </i> Mouse Model of Recessive Osteogenesis ImperfectaSemantic proximity Read ↗

Collagen XXVII organises the pericellular matrix in the growth plate.Semantic proximity Read ↗

The mechanical impact of <i>col11a2</i> loss on joints; <i>col11a2</i> mutant zebrafish show changes to joint development and function, which leads to early onset osteoarthritisSemantic proximity Read ↗

Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.