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Article

Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.

Circulation research - 28 Jun 2002

Chen Jun, Brodsky Sergey V, Goligorsky David M, Hampel Dierk J, Li Hong, Gross Steven S, Goligorsky Michael S

Abstract excerpt

Diabetic vasculopathy is central to the development of diverse cardiovascular, renal, retinal, and neurological complications of diabetes. We previously demonstrated that growth of endothelial cells on glycated extracellular matrix proteins (collagen and matrigel) results in a significant decrease in cell proliferation. In the present study, we show that early-passage human umbilical vein endothelial cells...

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Identifiers

PMID: 12089067
DOI: 10.1161/01.res.0000022161.42655.98

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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