Article
Formation of novel TRPC channels by complex subunit interactions in embryonic brain.
The Journal of biological chemistry - 3 Oct 2003
Strübing Carsten, Krapivinsky Grigory, Krapivinsky Luba, Clapham David E
Abstract excerpt
Mammalian short TRP channels (TRPCs) are putative receptor- and store-operated cation channels that play a fundamental role in the regulation of cellular Ca2+ homeostasis. Assembly of the seven TRPC homologs (TRPC1-7) into homo- and heteromers can create a large variety of different channels. However, the compositions as well as the functional properties of native TRPC complexes are largely undefined. We...
Topics
- Animals
- Blotting, Western
- Brain
- Calcium
- Calcium Channels
- Carbachol
- Cation Transport Proteins
- Cations
- Cell Line
- Cell Membrane
- Cloning, Molecular
- Diglycerides
- Dimerization
- Electrophysiology
- Genes, Dominant