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Article

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2010

Rivero-Müller Adolfo, Chou Yen-Yin, Ji Inhae, Lajic Svetlana, Hanyaloglu Aylin C, Jonas Kim, Rahman Nafis, Ji Tae H, Huhtaniemi Ilpo

Abstract excerpt

G protein-coupled receptors (GPCRs) are ubiquitous mediators of signaling of hormones, neurotransmitters, and sensing. The old dogma is that a one ligand/one receptor complex constitutes the functional unit of GPCR signaling. However, there is mounting evidence that some GPCRs form dimers or oligomers during their biosynthesis, activation, inactivation, and/or internalization. This evidence has been obtained...

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Identifiers

PMID: 20080658
DOI: 10.1073/pnas.0906695106
PMCID: PMC2836644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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