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Article

Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.

Cell reports - 29 Aug 2013

Kant Shashi, Barrett Tamera, Vertii Anastassiia, Noh Yun Hee, Jung Dae Young, Kim Jason K, Davis Roger J

Abstract excerpt

Saturated free fatty acid (FFA) is implicated in the metabolic response to obesity. In vitro studies indicate that FFA signaling may be mediated by the mixed-lineage protein kinase (MLK) pathway that activates cJun NH2-terminal kinase (JNK). Here, we examined the role of the MLK pathway in vivo using a mouse model of diet-induced obesity. The ubiquitously expressed MLK2 and MLK3 protein kinases have partially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 23954791
DOI: 10.1016/j.celrep.2013.07.019
PMCID: PMC3769115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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