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Article

Metabolic control by S6 kinases depends on dietary lipids.

PloS one - 1 Jan 2012

Castañeda Tamara R, Abplanalp William, Um Sung Hee, Pfluger Paul T, Schrott Brigitte, Brown Kimberly, Grant Erin, Carnevalli Larissa, Benoit Stephen C, Morgan Donald A, Gilham Dean, Hui David Y, Rahmouni Kamal, Thomas George, Kozma Sara C, Clegg Deborah J, Tschöp Matthias H

Abstract excerpt

Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dietary lipids in regulating the mTORC1/S6K system. Analysis of S6K phosphorylation in vivo and in vitro showed that dietary lipids activate S6K, and this effect is not...

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Share to Amino Acids, Branched-Chain
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fatty Acids, Nonesterified

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Source

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Identifiers

PMID: 22412899
DOI: 10.1371/journal.pone.0032631
PMCID: PMC3296718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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