Article
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2011
Becattini Barbara, Marone Romina, Zani Fabio, Arsenijevic Denis, Seydoux Josiane, Montani Jean-Pierre, Dulloo Abdul G, Thorens Bernard, Preitner Frédéric, Wymann Matthias P, Solinas Giovanni
Abstract excerpt
Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that PI3Kγ activity...
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