Article
Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2014
Ibrahim Samar H, Gores Gregory J, Hirsova Petra, Kirby Michelle, Miles Lili, Jaeschke Anja, Kohli Rohit
Abstract excerpt
BACKGROUND & AIMS: C-Jun N-terminal kinase (JNK) activation is pivotal in the development of nonalcoholic steatohepatitis (NASH). Mixed lineage kinase 3 (MLK) 3 is one of the mitogen activated protein kinase kinase kinase (MAP3K) that mediates JNK activation in the liver. Despite this concept, the role of MLK3 in modulating liver injury during nutrient excess has not been explored. Our aim was to determine if...
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