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Article

A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Nov 2013

Grant Jon E, Odlaug Brian L, Chamberlain Samuel R, Hampshire Adam, Schreiber Liana R N, Kim Suck Won

Abstract excerpt

Pathological gambling (PG) is a disabling disorder experienced by 1-3% of adults, and empirically validated treatments are lacking. Perturbations of prefrontal-dependent cognitive functions are implicated in the pathophysiology of PG. The enzyme catechol-O-methyl-transferase (COMT) is responsible for degradation of dopamine in the cortices and thereby is known to regulate such cognitive functions and their neural...

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Source

Identifiers

PMID: 23953269
DOI: 10.1016/j.euroneuro.2013.07.008

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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