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Article

Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 May 2007

Williams-Gray Caroline H, Hampshire Adam, Robbins Trevor W, Owen Adrian M, Barker Roger A

Abstract excerpt

Cognitive dysfunction commonly occurs even in the early stages of Parkinson's disease (PD). Impairment on frontostriatally based executive tasks is particularly well described but affects only a proportion of early PD patients. Our previous work suggests that a common functional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene underlies some of this executive heterogeneity. In...

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Identifiers

PMID: 17475791
DOI: 10.1523/JNEUROSCI.0774-07.2007
PMCID: PMC6672096

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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