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Article

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2004

Foltynie Thomas, Goldberg Terry E, Lewis Simon G J, Blackwell Andrew D, Kolachana Bhaskar S, Weinberger Daniel R, Robbins Trevor W, Barker Roger A

Abstract excerpt

Parkinson's disease (PD) patients show a range of executive deficits involving dopaminergic transmission in the prefrontal cortex. In this study, we have investigated the impact of catechol-O-methyl-transferase (COMT) val(158)met polymorphisms on performance of the Tower of London (TOL) test of planning by PD patients. Motor and cognitive assessments were performed on 288 patients as part of a population-based...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15300652
DOI: 10.1002/mds.20118

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism.PMID 15300652Read ↗

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