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Article

Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2014

Jacobsen Christina M, Barber Lauren A, Ayturk Ugur M, Roberts Heather J, Deal Lauren E, Schwartz Marissa A, Weis MaryAnn, Eyre David, Zurakowski David, Robling Alexander G, Warman Matthew L

Abstract excerpt

The cell surface receptor low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass and bone strength. Heterozygous missense mutations in LRP5 cause autosomal dominant high bone mass (HBM) in humans by reducing binding to LRP5 by endogenous inhibitors, such as sclerostin (SOST). Mice heterozygous for a knockin allele (Lrp5(p.A214V) ) that is orthologous to a human HBM-causing...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24677211
DOI: 10.1002/jbmr.2198
PMCID: PMC4130796

Genes

LRP5
HBM
SOST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta.PMID 24677211Read ↗

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